PI3K–AKT–mTOR pathway is activated in most human cancers, and studies showed activation of this signaling could suppress ferroptosis through regulating sterol regulatory element-binding protein 1 (SREBP1)-mediated lipid metabolisms.37 Apart from that, the transcriptional regulatory activity of Yes-associated protein (YAP) could promote ferroptosis.38 IL6ST, as an upstream of PI3K–AKT–mTORC1 pathways, might inhibit ferroptosis through regulating PI3K–AKT–mTORC1 pathways, and further research is needed to prove this hypothesis. This evidence concerns the gene IL6ST and cancer.