SREBF1 and cancer: PI3K–AKT–mTOR pathway is activated in most human cancers, and studies showed activation of this signaling could suppress ferroptosis through regulating sterol regulatory element-binding protein 1 (SREBP1)-mediated lipid metabolisms.37 Apart from that, the transcriptional regulatory activity of Yes-associated protein (YAP) could promote ferroptosis.38 IL6ST, as an upstream of PI3K–AKT–mTORC1 pathways, might inhibit ferroptosis through regulating PI3K–AKT–mTORC1 pathways, and further research is needed to prove this hypothesis.