Interleukin 6 cytokine family signal transducer activation in Adenomatous polyposis coli (APC) loss mice can accelerate CRC development depending on SFK and JAK pathways.28 Whether IL6ST is related to ferroptosis in CRC is unknown, and the current study intends to provide preliminary evidence for future clinical translation by observing whether IL6ST affects ferroptosis. This evidence concerns the gene APC and colorectal carcinoma.