PTGS2 and colorectal carcinoma: Furthermore, we explored the relationship between IL6ST and ferroptosis-related genes in CRC and found that IL6ST was significantly related to FTH1 (r = −0.116, P = .003), GPX4 (r = −0.369, P = 0.000), NCOA4 (r = 0.557, P = 0.000), PTGS2 (r = 0.458, P = .000), SLC7A11 (r = 0.434, P = .000), and TFRC (r = 0.201, P = .256E−07) (Figure 1F).