IRS1 and Alzheimer disease: RT‐qPCR results demonstrated that after DSS intervention, the mRNA relative expression levels of IRS1 and GSK3β decreased compared with those in the AD group (**p < 0.01), whereas the relative mRNA expression levels of Wnt and β‐catenin increased compared with those in the AD group (*p < 0.05, **p < 0.01), thereby confirming the regulatory role of DSS on the pathway at the genetic level (Figure 7H).