Here, using postmortem human brain samples, we found abnormal accumulation of hyperphosphorylated tau protein in the hippocampus and medial entorhinal cortex within 4–13 months post clinically recovery from acute COVID‐19, together with prolonged activation of glia cells and increases in inflammatory factors, even though no SARS‐COV‐2 invasion was detected in these regions. The gene discussed is MAPT; the disease is COVID-19.