Moreover, in the present study, SFC‐fed mice treated with 4MP were not protected from the development of insulin resistance, suggesting that, in settings of diet‐induced non‐obese MASLD, other (TNFα‐dependent) signalling cascades bypassing JNK signalling may be critical in the development of insulin resistance. This evidence concerns the gene MAPK8 and metabolic dysfunction-associated steatotic liver disease.