Transcriptome sequencing of buccal mucosa from MED1 epithelial-specific knockout mice and control mice revealed enrichment of immune and autoimmune disease pathways within the KEGG annotation results of differentially expressed genes in the entry of “human disease”, such as Epstein-Barr virus infection, autoimmune thyroid disease, and systemic lupus erythematosus (Fig. S9A). The gene discussed is MED1; the disease is Epstein-Barr virus infection.