CNN2 and Familial prostate cancer: Recent inquiries into CNN2 have linked it to cancer biology, with notable expression in breast and prostate cancers, suggesting a role in tumor growth regulation.72 Moreover, CNN2 deletion in macrophages has been associated with attenuated development of inflammatory arthritis73 and atherosclerosis74 in murine models, indicating its significance in mechanoregulation within macrophage-mediated diseases.