More in keeping with its growth inhibitory role during development there is convincing evidence that GRB10 acts as a tumour suppressor in at least two cases, that of clear cell renal cell carcinoma [43] and in tumours from a cancer-prone mouse model heterozygous for the Neurofibromatosis 1 (Nf1) gene [44]. The gene discussed is NF1; the disease is clear cell renal carcinoma.