STAT3 and lung cancer: Similarly, compared to normal human embryonic lung fibroblast cells (2BS), miR-4458 was found to be downregulated in human NSCLC cell lines (~1.6 fold in H1299, ~1.9 fold in A549 and ~1.4 fold in SW900) (p < 0.01), whereas a higher expression level of STAT3 was reported in lung cancer cells (~1.6 fold in H1299, ~1.734 fold in A549, and ~1.75 fold in SW900) (p < 0.01).