TFRC and Alzheimer disease: The MR analysis of the correlation between Tfrc and AD revealed significant results of the IVW method (OR = 1.082, 95% CI = 1.012–1.156, P = 0.021), MR-Egger’s method (OR = 0.970, 95%CI = 0.776–1.211, P = 0.791), and weighted median method (OR = 1.057, 95%CI = 0.965–1.159, P = 0.234) (Supplementary Table 1 and Supplementary Fig. 5), suggesting a positive genetic relationship between Tfrc and AD.