The synergistic effect of combination therapy is linked to the multiple immunostimulatory effects induced by chemotherapies in the tumor microenvironment.8 9 These include increased antigen presentation and dendritic cell activation,10 11 altered immune checkpoint expression,12 increased immunogenic cell death,13 depletion of immunosuppressive cells14 15 and increased activation and proliferation of tumor infiltrating lymphocytes (TILs) including CD8+ T cells.16 17. The gene discussed is CD8A; the disease is neoplasm.