CD8A and neoplasm: Two doses of GEM significantly increased the frequency of endogenous tumor infiltrating Thy1.1− CD8+ TPEX (27.5±9.89% in PBS to 66.7±6.21% in GEM; p≤0.0001), but not frequencies in the HA-specific Thy1.1+ CD8+ TPEX (figure 3B,C).