Notably, transcripts of several mesenchymal signature biomarkers were significantly elevated in MT cells (Fig. 5A) and considering their association with EMT and poor survival in MLL1-AF9 AML patients (18), we aimed to investigate whether the loss of MLL1 activity was linked to EMT-associated cancer stem cell formation and increased invasiveness. This evidence concerns the gene KMT2A and acute myeloid leukemia.