SOX9 has been broadly studied in the field of cancer stem cells, and high SOX9 expression is related to the promotion of self‐renewal.[19, 24, 43] Recent studies have revealed that SOX9 contributes to chemotherapy resistance and is associated with DDR.[62, 63] However, marked transcriptional activation was observed in Linc00492‐overexpressing LN229, U251, HG7, and HG11 cells and TMZ‐resistant LN229R, U251R, HG7R, and HG11R cells, but not in MUT‐1 and MUT‐2 cells, and knockout of Linc00942 significantly suppressed SOX9 expression. This evidence concerns the gene LINC00492 and cancer.