PKM and neoplasm: Previous studies have shown that both TPI1 and PKM2 regulate the acetylation of histones, thereby contributing to tumor progression.[7, 10] Our results showed a significant decrease in HDAC3 activity and a significant increase in H3K4ac expression in Linc00942‐overexpressing LN229, U251, HG7, and HG11 cells and in TMZ‐resistant LN229R, U251R, HG7R, and HG11R cells.