H3K4 acetylation in specific promoter regions can be regulated by both HDAC3 and p300, which can contribute to marked transcriptional changes.[41, 42] To determine how Linc00942‐induced transcriptional alterations contribute to TMZ resistance in GBM cells, we analyzed the expression of STAT target genes using a heat map (Figure 5A). This evidence concerns the gene HDAC3 and glioblastoma.