Specifically, YTHDF2, by interacting with RBM4, facilitates the degradation of m6A-modified mRNAs of Signal Transducer and Activator of Transcription 1 (STAT1), thereby inhibiting the polarization of M1 TAMs, consequently diminishing both the innate and adaptive anti-tumor immunity of TAMs [64]. The gene discussed is YTHDF2; the disease is neoplasm.