Subsequently, YTHDF1 can exert its tumorigenic effects by targeting Polo Like Kinase 1 (PLK1) in an m6A-dependent manner, which facilitates the hyperactivation of the PI3K/AKT signaling pathway, thereby promoting PCa tumorigenesis and metastasis both in vitro and in vivo [132]. The gene discussed is YTHDF1; the disease is posterior cortical atrophy.