For example, METTL3-mediated m6A modification upregulates circular Ubiquitin Like With PHD And Ring Finger Domains 2 (circUHRF2), subsequently recruiting IGF2BP1 to inhibit the degradation of DEAD-box helicase 27 (DDX27) protein, thereby enhancing CRC stemness and metastasis [93]. Here, DDX27 is linked to colorectal carcinoma.