IGF2BP2, by targeting genes involved in glutamine (Gln) metabolism, such as Glutamic–Pyruvic Transaminase 2 (GPT2), Solute Carrier Family 1 Member 5 (SLC1A5), and MYC, supports the self-renewal of leukemia stem cells and progenitor cells, thereby facilitating AML progression. Here, MYC is linked to acute myeloid leukemia.