Odd-skipped related 2 (Osr2) is a mechanoresponsive transcription factor, which is selectively induced in terminally exhausted tumor-specific CD8+ T cell subsets by TCR signal transduction and biomechanical stress mediated by the Piezo1/Ca2+/cyclic adenosine monophosphate(cAMP)-response element binding protein (CREB) axis. This evidence concerns the gene CD8A and neoplasm.