CD3E and neoplasm: TCRαβ chains are recombinantly expressed as soluble single-chain heterodimers, which are then fused with a single-chain variable fragment (ScFv) derived from an anti-CD3ε antibody through a flexible linker to generate a bispecific protein that can simultaneously target polyclonal T cells and tumor cells expressing specific p-MHC complexes, known as ImmTAC [116].