CD8A and neoplasm: At the same time, small soluble proteins that target both tumor cells and T cells can overcome the biophysical characteristics of tumors, utilize natural antigen presentation pathways and specific antigen recognition structures to target tumor cells, trigger the relocation of polyclonal CD8+ T cells in the interstitium, promote the formation of immune synapses, and ultimately transform the immune rejection phenotype of the tumor into an immune inflammation phenotype (Fig. 3b).