Similarly, in the RCT by Silva et al. [40], treatment with ACE inhibitors (enalapril) (initiated at a LVEF > 50%) was found to be associated with slower myocardial fibrosis (MF) progression identified on cardiovascular magnetic resonance among 42 Brazilian patients (39 with DMD and three with Becker muscular dystrophy [BMD], a milder allelic condition also caused by in-frame mutations in the DMD gene; mean age: 12 years, range not reported) across 24 months of follow-up. This evidence concerns the gene ACE and Duchenne muscular dystrophy.