Through an immunomic analysis of macrophage subsets in IPFP of patients with osteoarthritis (OA) in the knee, Patchanika et al. discovered that OA-related genes were expressed at higher levels in CD11c + CD206 + macrophages as opposed to CD11c + CD206-, CD11c-CD206+, and CD11c-CD206- macrophages [19]. Here, ITGAX is linked to osteoarthritis.