PSEN1 and Alzheimer disease: The in vitro experiments showing protective role of rAIBP (Figs. 1 and 4) and the increased TLR4 inflammarafts, distorted microglial mitochondria, ER stress, and oxidative stress in Apoa1bp−/− APP/PS1 brain (Figs. 2, 3 and 5) suggest that AIBP deficiency might result in exacerbated AD-like pathology.