HIPK2 and familial pancreatic carcinoma: This is consistent with i) cancer genome data retrieved from publicly available databases (e.g., COSMIC, cBioPortal) that report the presence of the wild-type HIPK2 gene in the majority of pancreatic cancers, ii) our previous data obtained on PDAC mRNA samples showing transcription of different HIPK2 isoforms [41], and iii) the increased expression of HIPK2 mediated by NRF2, a target of oncogenic RAS in different tumor cell types [44].