HIPK2 and neoplasm: Indeed, in a previous study on Panc1 and SW1990 PDAC cell lines, it has been shown that very high levels of HIPK2 expression, achieved through exogenous HIPK2 overexpression, inhibit, rather than supporting, ERK phosphorylation and induce tumor-suppressive effects by reducing cMyc and cMyc‐targeted glycolytic genes expression [40].