KRAS and keratoconus: When administered for two months to KC mice, we observed a complete prevention of both ADM and PanIN formation in five out of six of the 5-ITu treated mice while the opposite results (i.e., ADM and PanIN formation in five out of six animals) were obtained in the control, DMSO-treated mice, indicating a strong chemoprevention activity of 5-ITu in KRAS-driven pancreatic tumorigenesis.