The mean/median duration of HIV infection ranged from 7.6 months to 21.8 years [41, 42], the mean/median duration of ART ranged from 13 months to 18.8 years [43, 44], and the mean/median CD4 + cell count was between 105.3 and 803 cells/μL [39, 45]. This evidence concerns the gene CD4 and HIV infectious disease.