PFKFB3 and neoplasm: 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) is one of the critical enzyme of the glycolytic pathway and an increased mRNA expression of PFKFB3 is well documented in aggressive neoplasm of ovary, colon and breast [52] and in gastric cancer tissue [53].