Among them, APOE, B4GALT1, NRXN1, NRXN2, and LCAT are involved in the cell adhesion molecules pathway, cholesterol metabolism pathway, and glycan biosynthesis pathway in PSP versus PD plus HC of GSEA, further suggesting a potential connection of cell adhesion molecule and cholesterol metabolism pathways to PSP. The gene discussed is LCAT; the disease is supranuclear palsy, progressive, 1.