While ATP1B2, CNTNAP2, EPDR1, FBLN2, GGH, GOT1, HAPLN4, PREP, and SERPINE2 were the main differentially expressed proteins common in CSF and GP of PSP patients, they were not identified as the key proteins in GSEA, interactome analysis, and ROC analyses. The gene discussed is EPDR1; the disease is supranuclear palsy, progressive, 1.