OGG1 and cancer: In this regard for cancer, our group has found that OGG1 interaction with the ROS-damaged base 8-oxoG is the upstream event that leads to the transcriptional repression NURD complex binding to the gene start sites in the CpG islands, and the NURD interaction triggers cancer-specific DNA hypermethylation associated with abnormal silencing of tumor suppressor genes (TSG’s) and abnormalities of immune function20.