According to a study by Shi et al., a WBC count >20 ×109/L or <5 ×109/L and a CRP > 50 mg/L are independent risk factors for surgical NEC.24 Previous studies have confirmed the value of the PLT in predicting surgical intervention and mortality in patients with NEC.25,26 Ververidis et al. reported that the lowest PLT during NEC was lower in patients with stage III NEC than in patients with stage II NEC, and similar results were observed between patients who died and those who survived. This evidence concerns the gene CRP and necrotizing enterocolitis.