APP and Hepatic fibrosis: However, the comparison of infants with advanced and less advanced fibrosis scores (Ishak fibrosis score >4 vs. <5) showed an increased expression of 4 amyloid-related genes (ADAM9, APP, MMP7, and MMP14) and a decreased expression of 2 amyloid-related genes (APOA1, APOA2) in infants with more advanced liver fibrosis.