PAX8 and neoplasm: Profiling clustered sub-populations highlights heterogeneity of gene, peak and motif activity within tumour sub-populations (Fig. S8) All samples had prominent EPCAM, LAPTM4B, KRT7, PAX8 gene activity plus MEIS1 motif enrichment, supporting epithelial cell type, but other tumour markers including MUC16 showed more sample-wise variation (Fig. 5B).