The WS mouse with double knocked out of the telomerase RNA components mTerc and Wrn gene (mTR−/−Wrn−/−), faithfully reproduced the phenotypes of human Werner syndrome, such as shortened lifespan, cataract, type II diabetes mellitus, osteoporosis, ischemic heart disease, osteosarcoma, etc. [19, 20]. The gene discussed is WRN; the disease is Werner syndrome.