PKM and cancer: This increase in HNRNPA1 expression is driven by the oncogenic transcription factor c-Myc.30 Despite the substantial overexpression of MYC, HNRNPA1, and PKM2 in most tumors,30,74,75 it is important to note that the MYC-HNRNPA1-PKM2 axis is not universally responsible for tumorigenesis and tumor progression across all cancer types.76 This observation suggests the existence of regulatory mechanisms that can modulate or inhibit the activity of this axis.