We discovered that ZMYND11 can physically interact with HNRNPA1 via its MYND domain, and this interaction is crucial for ZMYND11 to counteract HNRNPA1-induced aggressive phenotypes in prostate cancer cells (Figs. 3, 4 and Supplementary Figs. 3, 4). Here, ZMYND11 is linked to prostate carcinoma.