Interestingly, transcriptomic analysis of hCHF-LMS showed enrichment of the nuclear factor-erythroid 2-related factor 2 (NRF2) pathway, which is a master regulator of the antioxidant response and has been shown to regulate the activity of several ferroptosis and lipid peroxidation-related proteins in cancer and neurode-generative diseases [50,51]. The gene discussed is NFE2L2; the disease is cancer.