However, the host can prevent iron uptake by pathogenic bacteria by releasing lactoferrin (chelating Fe3+), lipocalin-2 (LCN2) (sequestering siderophores), and calprotectin (CP) (sequestering Fe2+) from neutrophils or IECs at the sites of infection [[79], [80], [81]] (Figure 2B). This evidence concerns the gene LCN2 and infection.