UHRF1 and lung adenocarcinoma: However, UHRF1 was also a proto-oncogene that overexpressed in several tumor tissues (43, 45, 46, 47) and high UHRF1 expression is a marker of poor prognosis in human KRAS mutant lung adenocarcinoma (48), while the exact role of UHRF1 in tumorigenesis remains elusive.