There was also a prominent increase in the marginal zone and white pulp macrophages such as marginal zone macrophages (MHCII+ CD209b+), marginal metallophilic macrophages (MHCII+ CD169+), and tingible body macrophages (MHCII+ CD68+) (Figs. 7, C–E and S4) between day 7 and 11 post-infection. This evidence concerns the gene CD68 and infection.