Knocking out the DNMT2/TRDMT1 gene in drug-treated glioblastoma cells led to a decrease in the number of apoptotic and senescent cells, a reduction in interleukin-8 levels and autophagy, and an increase in the number of necrotic cells, compared with those observed in drug-treated glioblastoma cells with unmodified levels of DNMT2/TRDMT1 [115]. The gene discussed is TRDMT1; the disease is glioblastoma.