Consistent with this assumption, a comparison of differentially expressed genes in mice lacking Fgfr1 and Fgfr2 in keratinocytes18 with microarray data from laser-capture isolated epidermis of lesional AD and control skin29 via gene set enrichment analysis (GSEA) showed a significant enrichment of the upregulated genes (Figure 7E). This evidence concerns the gene FGFR1 and Alzheimer disease.