HT29 colorectal cancer cells expressing the BRAF V600E mutation showed an increased activation of YAP and cytosolic CLDN4 whilst a decrease in membranous CLDN4, compared to HCT116 BRAF wild-type cells, which showed no YAP activation or changes in CLDN4 when treated with CPE for 24 h. Here, CLDN4 is linked to colorectal cancer.