This finding, however, is not surprising considering the fact that angiotensin-converting enzyme-2 (ACE2), transmembrane serine protease-2 (TMPRSS2), and particularly neuropilin-1 (NRP1), all facilitating the entry of SARS-CoV-2 into the CNS, are also found in GBM tissue, as well as in organoids and cell lines (Suarez-Meade et al. 2023). This evidence concerns the gene ACE2 and glioblastoma.