NF1 + melanomas constitute about 12–23% of melanoma patients (TCGA Network 2015; Hayward et al. 2017; Newell et al. 2022) and are characterized by the highest mean rate of mutations (39 mutations/MB), stronger than BRAF + subtype UV signature correlation, and worst overall survival (TCGA Network et al. 2015; Cirenajwis et al. 2017). The gene discussed is BRAF; the disease is melanoma.