Coronary artery microembolization‐induced CHF in canines up‐regulates myocardial nNOS and inducible NOS expression (Ruble et al., 2010; Sabbah, 2011), whilst downregulating eNOS (Sabbah, 2011), whilst VNS normalizes the expression of nNOS and improves iNOS and eNOS expression (Ruble et al., 2010; Sabbah, Gupta et al., 2011; Sabbah, Ilsar et al., 2011). The gene discussed is NOS2; the disease is congestive heart failure.