This was true especially for the healthy recipients receiving simultaneous vaccination, but also for T2D subjects in which the production of IFN-γ and CXCL10 was induced in a similar fashion to that of HS, while the inflammatory factors IL-15, IL-6 and TNF-α were already high at basal level before vaccine co-administration and only slightly increased 1 day after, consistently with cytokine dysregulation and chronic inflammation occurring in these individuals [53,54]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.