First, to obtain a global view of the phenotypic landscape of T-lymphocyte compartment in the PBMCs, we studied the distribution and numbers of CD4+ and CD8+ T lymphocytes and their TN, TCM, TEM, and TE activation subsets in patients with B-NHL, MM, or CLL with respect to HCs after two administrations of SARS-CoV-2 vaccination. This evidence concerns the gene CD8A and B-cell chronic lymphocytic leukemia.