Analysis of cerebrospinal fluid (CSF) and serum samples collected for arbovirus investigation identified four neonates having microcephaly; IgM antibodies against OROV were identified from serum in infants at day of life (DOL) 1 and 27 and, in CSF, in two newborns at DOL 1 and DOL 27. This evidence concerns the gene CD40LG and microcephaly.