However, SQV did appear to have a significant effect in terms of the tumor-free survival; in particular, the CD4-depleted mice treated with SQV + DMBA (12/18) had a statistically significant increase in tumor-free survival as compared to the CD4-depleted DMBA-treated mice (15/19) (p-value = 0.0255) Similar findings were noted for the overall survival. Here, CD4 is linked to neoplasm.