CD4 and cancer: With CD4 depletion, there were worsening grades of histological disease in a couple of the treatment groups (control vs. control with CD4 depletion (p-value = 0.0462), SQV vs. SQV with CD4 depletion (p-value < 0.0001) and interestingly less cancer in the DMBA with CD4 compared to DMBA alone (p-value < 0.001).