Control of the antiviral response due to OXPHOS in this phase of infection would therefore be achieved by the regulation of endoplasmic reticulum–mitochondria interfaces as demonstrated by the ability of DENV NS4B to regulate mitochondrial fission by the inhibition of DRP1, leading to mitochondria-associated membrane disruption and thus the subsequent inhibition of the RIG-I-dependent antiviral response [25]. This evidence concerns the gene RIGI and infection.