CD80 has been reported to suppress immune cells [49,50] and also to play a part in increasing inflammatory cascades, as reported in a polymicrobial sepsis model [51]; however, in our current study, on day 7 PI, in the CD80-/- mice infected with dLAT2903 virus, the corneas of the infected mice displayed enhanced IFN-γ expression as compared to all other groups (Figure 5A; p < 0.05). The gene discussed is IFNG; the disease is Sepsis.