Based on the aforementioned observations, in order to explore the changes in the NLRP3 inflammasome pathway in the hippocampus of mice showing SD-induced anxiety-like behavior, RT-qPCR was utilized to detect the mRNA expression levels of the key factors NLRP3, ASC, and caspase-1 in the NLRP3 inflammasome pathway. The gene discussed is NLRP3; the disease is Anxiety.