INS and Disorder of lipid metabolism: Although we found that Cv2 did not significantly influence glucose tolerance or insulin sensitivity in HFD-induced female obese mice, we observed that the supplementation of Cv2 could alleviate the increase in serum and hepatic lipid levels, as well as liver injury marker levels, induced by the HFD in mice, which may be attributed to the protective effects of Cv-derived endogenous Se on lipid metabolic disorder and liver injury induced by a HFD and Cd [23,29,42].