IGHE and hereditary elliptocytosis: Children over 12 months of age with IgE-mediated HEA, defined by a history of a type I hypersensitivity reaction to HE and a positive HE SPT (wheal > 3 mm) and/or detectable HE sIgE (≥0.35 kUA/L), who tolerated BE, were randomly assigned to a short- or long-duration protocol for HE tolerance induction.