This beneficial effect occurs through (a) the suppression of stem cell markers (such as CD44) [22] and cell adhesion molecules like uPAR/PAI-1, which are involved in tumor progression and metastasis, (b) the cell cycle inhibition [46], and (c) the increase in cell death by apoptosis [22,23,47,48]. The gene discussed is PLAUR; the disease is neoplasm.