IL4 and experimental autoimmune encephalomyelitis: Haghmorad et al. (2020) observed that the improvement in the defense system after kombucha treatment was related to the increased production of Th2 and Treg cytokines (IL-4 and TGF-β) and lower production of Th1 and Th17 cytokines (IFN-γ and IL-17) in experimental autoimmune encephalomyelitis-induced mice [59].