PRKAA2 and obesity due to melanocortin 4 receptor deficiency: Furthermore, obesity and adipogenesis are linked to alterations in various signaling pathways within the WAT, with 5’-adenosine monophosphate (AMP)-activated protein kinase (AMPK) emerging as a pivotal regulator due to its anti-adipogenic effects across multiple tissues, including the liver and skeletal muscle [16,17].