GLP1R and hydrops fetalis: Although more evidence is needed, current recommendations do not purport GLP-1 RAs as protective in overweight/obese patients (BMI > 25 kg/m2) with pre-existing advanced HFrEF; GLP-1 RA treatment may increase the risk of HF rehospitalization (HR 1.33, 95% CI 0.83–2.12) [63], although evolving evidence suggests GLP-1 RA could certainly benefit those with HFpEF [64].